Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/8149
Title: Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant
Authors: Garcia, Leandro de Borborema
Cunha Junior, Armando da Silva
Fialho, Silvia Ligório
Perez, André Coura
Barros, Bruno Borges de Carvalho
Dorigueto, Ricardo Schaffeln [UNIFESP]
Testa, Jose Ricardo Gurgel [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Federal University of Minas Gerais Faculty of Pharmacy
Federal University of Minas Gerais
Universidade de São Paulo (USP)
Keywords: Biopolymers
Inflammation
Ear, Middle
Guinea Pigs
Issue Date: 1-Jan-2014
Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Citation: Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, p. 12-18, 2014.
Abstract: PURPOSE:To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant.METHODS:A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively).RESULTS:Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2.CONCLUSION:The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant.
URI: http://repositorio.unifesp.br/handle/11600/8149
ISSN: 0102-8650
Other Identifiers: http://dx.doi.org/10.1590/S0102-86502014001300003
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