Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/7947
Title: Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing
Authors: Neves, Paulo Cesar Fagundes
Abib, Simone de Campos Vieira [UNIFESP]
Neves, Rogerio Fagundes [UNIFESP]
Pircchio, Oronzo
Saad, Karen Ruggeri [UNIFESP]
Saad, Paulo Fernandes [UNIFESP]
Simoes, Ricardo Santos [UNIFESP]
Moreira, Marcia Bento
Laurino, Cristiano Frota de Souza
Universidade Federal do Vale do Sao Francisco Colegiado de Medicina
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Vale do Sao Francisco Colegiado de Medicina Veterinaria
Sociedade Brasileira de Traumatologia Esportiva e Artroscopia
Keywords: Hyperbaric Oxygenation
Platelet-rich Plasma
Fibula, Fracture Consolidation
Issue Date: 1-Sep-2013
Publisher: Faculdade de Medicina / USP
Citation: Clinics. Faculdade de Medicina / USP, v. 68, n. 9, p. 1239-1246, 2013.
Abstract: OBJECTIVES: The purpose is to study the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing the fibula bone of rabbits after induced fractures. METHODS: A total of 128 male New Zealand albino rabbits, between 6-8 months old, were subjected to a total osteotomy of the proximal portion of the right fibula. After surgery, the animals were divided into four groups (n = 32 each): control group, in which animals were subjected to osteotomy; autologous platelet concentrate group, in which animals were subjected to osteotomy and autologous platelet concentrate applied at the fracture site; hyperbaric oxygen group, in which animals were subjected to osteotomy and 9 consecutive daily hyperbaric oxygen therapy sessions; and autologous platelet concentrate and hyperbaric oxygen group, in which animals were subjected to osteotomy, autologous platelet concentrate applied at the fracture site, and 9 consecutive daily hyperbaric oxygen therapy sessions. Each group was divided into 4 subgroups according to a pre-determined euthanasia time points: 2, 4, 6, and 8 weeks postoperative. After euthanasia at a specific time point, the fibula containing the osseous callus was prepared histologically and stained with hematoxylin and eosin or picrosirius red. RESULTS: Autologous platelet concentrates and hyperbaric oxygen therapy, applied together or separately, increased the rate of bone healing compared with the control group. CONCLUSION: Hyperbaric oxygen therapy and autologous platelet concentrate combined increased the rate of bone healing in this experimental model.
URI: http://repositorio.unifesp.br/handle/11600/7947
ISSN: 1807-5932
1980-5322
Other Identifiers: http://dx.doi.org/10.6061/clinics/2013(09)11
Appears in Collections:Artigo

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