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Title: Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations
Authors: Murad, Neif [UNIFESP]
Tucci, Paulo José Ferreira [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: contractile function
developed pressure
wall stress
cardiac hypertrophy
Laplace's law
Issue Date: 1-Jun-1999
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 6, p. 773-776, 1999.
Abstract: We report data showing that developed pressure (DPmax) may lead to opposite conclusion with respect to maximal developed circumferential wall stress (smax) when used to assess contractile function in left ventricle isovolumic preparations. Isovolumetric left ventricle preparations of rats with cardiac hypertrophy (H; N = 10) induced by isoproterenol administration showed higher DPmax (174 ± 14 mmHg) than control (C; N = 8) animals (155 ± 12 mmHg) or rats with regression (R; N = 8) of hypertrophy (144 ± 11 mmHg). In contrast, the estimated smax for C (145 ± 26 kdynes/cm2) and R (133 ± 17 kdynes/cm2) was higher than for H (110 ± 13 kdynes/cm2). According to Laplace's law, the opposite results of DPmax and smax may depend on the increased mass/volume left ventricle ratio of the hypertrophied hearts, which favored pressure generation. These results clearly show that DPmax should be used with caution to analyze systolic function.
ISSN: 0100-879X
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