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Title: Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
Authors: Nader, Helena Bonciani [UNIFESP]
Chavante, Suely Ferreira [UNIFESP]
Santos, Elizeu Antunes dos
Oliveira, Fernanda Wanderley
Paiva, José Fernandes de [UNIFESP]
Jerônimo, Selma Maria Bezerra
Medeiros, Guilherme Fulgencio de [UNIFESP]
Abreu, Luiz Roberto Diz de [UNIFESP]
Leite, Edda Lisboa
Sousa-Filho, João Felipe de
Castro, Rodrigo de Aquino [UNIFESP]
Toma, Leny [UNIFESP]
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Dietrich, Carl Peter [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio Grande do Norte
Universidade de Mogi das Cruzes
Keywords: heparin - occurrence and function
heparan sulfate - occurrence and function
heparin - invertebrates
heparan sulfate - invertebrates
heparin and heparan sulfate - structure
Issue Date: 1-May-1999
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999.
Abstract: The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.
ISSN: 0100-879X
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