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dc.contributor.authorGelatti, Luciane Cristina
dc.contributor.authorBonamigo, Renan Rangel
dc.contributor.authorInoue, Fernanda Matsiko [UNIFESP]
dc.contributor.authorCarmo, Mirian Silva do [UNIFESP]
dc.contributor.authorBecker, Ana Paula
dc.contributor.authorCastrucci, Fernanda Marques da Silvan [UNIFESP]
dc.contributor.authorPignatari, Antonio Carlos Campos [UNIFESP]
dc.contributor.authord'Azevedo, Pedro Alves [UNIFESP]
dc.identifier.citationRevista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 46, n. 1, p. 34-38, 2013.
dc.description.abstractINTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen commonly associated with nosocomial infections. However, it has also been associated with community-acquired skin and soft tissue infections (CA-MRSA). There are few data on the identification and prevalence of CA-MRSA infections in Brazil. METHODS: This is a cross-sectional study of 104 patients with community-acquired skin infections attending two health care centers in Porto Alegre, southern Brazil. MRSA isolates were characterized by molecular methods, including detection of the mecA gene by PCR, gene SCCmec typing, Panton-Valentine leukocidin (PVL) detection, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). RESULTS: From the 104 samples, 58 Staphylococcus aureus isolates were obtained, of which five (8.6%) had a CA-MRSA-resistant profile. All five isolates had the mecA gene and amplified to SCCmec type IV. Analysis of chromosomal DNA by PFGE revealed the presence of two clusters related to international clones (OSPC and USA 300), with a Dice similarity coefficient >80%. The study was complemented by MLST, which detected three different strains: ST30, ST8, and ST45, the latter not presenting any relation with the clones compared in PFGE. CONCLUSIONS: The presence of CA-MRSA reveals an important change in the epidemiology of this pathogen and adds new elements to the knowledge of the molecular biology of infections by MRSA with SCCmec type IV in southern Brazil.en
dc.publisherSociedade Brasileira de Medicina Tropical - SBMT
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical
dc.rightsAcesso aberto
dc.subjectStaphylococcus aureusen
dc.subjectSkin infectionsen
dc.subjectSoft tissue infectionsen
dc.titleCommunity-acquired methicillin-resistant Staphylococcus aureus carrying SCCmec type IV in southern Brazilen
dc.contributor.institutionUniversidade Federal de Ciências da Saúde de Porto Alegre Laboratório de Cocos Gram-positivos
dc.contributor.institutionFaculdade Serra da Mesa
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de Ciências da Saúde de Porto Alegre Laboratório de Cocos Gram-positivos
dc.description.affiliationFaculdade Serra da Mesa
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Laboratório Especial de Microbiologia Clínica
dc.description.affiliationUnifespUNIFESP, Laboratório Especial de Microbiologia Clínica
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