Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/728
Title: Effect of thyroparathyroidectomy on urinary acidification in diabetic rats
Authors: Gil, Frida Zaladek [UNIFESP]
Cavanal, Maria de Fátima [UNIFESP]
Nascimento-Gomes, G. [UNIFESP]
Silva-Rocha, M.c. [UNIFESP]
Nutti-de-Almeida, M. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: diabetes
thyroparathyroidectomy
renal function
acid excretion
Issue Date: 1-Jan-1999
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 1, p. 107-113, 1999.
Abstract: In previous studies we have shown stimulation of renal acid excretion in the proximal tubules of rats with diabetes of short duration, with no important alterations in glomerular hemodynamics; on the other hand, in thyroparathyroidectomized rats (TPTX model), a significant decrease in renal acid excretion, glomerular filtration rate (GFR) and renal plasma flow (RPF) was detected. Since important changes in the parathyroid hormone-vitamin D-Ca axis are observed in the diabetic state, the present study was undertaken to investigate the renal repercussions of thyroparathyroidectomy in rats previously made diabetic by streptozotocin (45 mg/kg). Four to 6 days after the induction of diabetes (DM), a group of rats were thyroparathyroidectomized (DM + TPTX). Renal functional parameters were evaluated by measuring the inulin and sodium para-aminohippurate clearance on the tenth day. The decrease in the GFR and RPF observed in TPTX was not reversed by diabetes since the same alterations were observed in DM + TPTX. Net acid (NA) excretion was unchanged in DM (6.19 ± 0.54), decreased in TPTX (3.76 ± 0.25) and returned to normal levels in DM + TPTX (5.54 ± 0.72) when compared to the control group (6.34 ± 0.14 µmol min-1 kg-1). The results suggest that PTH plays an important vasodilator role regarding glomerular hemodynamics, since in its absence the impairment in GFR and RPF was not reversed by the diabetic state. However, with respect to acid excretion, the presence of diabetes was able to overcome the negative stimulus represented by TPTX.
URI: http://repositorio.unifesp.br/handle/11600/728
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/S0100-879X1999000100016
Appears in Collections:Em verificação - Geral

Files in This Item:
File Description SizeFormat 
S0100-879X1999000100016.pdf182.57 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.