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Title: Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV
Authors: Machado, Daisy Maria [UNIFESP]
Fink, Maria Cristina
Pannuti, Cláudio Sérgio
Succi, Regina Célia de Menezes [UNIFESP]
Machado, Alessandra Aparecida
Carmo, Fabiana Bononi do [UNIFESP]
Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]
Urbano, Paulo Roberto
Beltrão, Suênia Vasconcelos [UNIFESP]
Santos, Isabel Cristina Lopes dos [UNIFESP]
Machado, Clarisse Martins [UNIFESP]
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: HIV-1
JC virus
BK virus
Issue Date: 1-Dec-2011
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Citation: Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 931-935, 2011.
Abstract: The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance.
ISSN: 0074-0276
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