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dc.contributor.authorPadilha, Heloisa Vidigal Guarita [UNIFESP]
dc.contributor.authorCrispim, Cibele Aparecida [UNIFESP]
dc.contributor.authorZimberg, Ioná Zalcman [UNIFESP]
dc.contributor.authorSouza, Daurea Abadia de
dc.contributor.authorWaterhouse, Jim Maris
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 992-999, 2011.
dc.description.abstractThe present review evaluates the role of sleep and its alteration in triggering problems of glucose metabolism and the possible involvement of adipokines in this process. A reduction in the amount of time spent sleeping has become an endemic condition in modern society, and a search of the current literature has found important associations between sleep loss and alterations of nutritional and metabolic contexts. Studies suggest that sleep loss is associated with problems in glucose metabolism and a higher risk for the development of insulin resistance and type 2 diabetes mellitus. The mechanism involved may be associated with the decreased efficacy of regulation of the hypothalamus-pituitary-adrenal axis by negative feedback mechanisms in sleep-deprivation conditions. In addition, changes in the circadian pattern of growth hormone (GH) secretion might also contribute to the alterations in glucose regulation observed during sleep loss. On the other hand, sleep deprivation stress affects adipokines - increasing tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and decreasing leptin and adiponectin -, thus establishing a possible association between sleep-debt, adipokines and glucose metabolism. Thus, a modified release of adipokines resulting from sleep deprivation could lead to a chronic sub-inflammatory state that could play a central role in the development of insulin resistance and type 2 diabetes mellitus. Further studies are necessary to investigate the role of sleep loss in adipokine release and its relationship with glucose metabolism.en
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectGlucose metabolismen
dc.subjectInsulin resistanceen
dc.subjectSleep lossen
dc.subjectType 2 diabetes mellitusen
dc.subjectInflammatory statusen
dc.titleA link between sleep loss, glucose metabolism and adipokinesen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Uberlândia Faculdade de Medicina
dc.contributor.institutionLiverpool John Moores University Research Institute for Sport and Exercise Sciences
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Psicobiologia
dc.description.affiliationUniversidade Federal de Uberlândia Faculdade de Medicina
dc.description.affiliationLiverpool John Moores University Research Institute for Sport and Exercise Sciences
dc.description.affiliationUnifespUNIFESP, Depto. de Psicobiologia
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