Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/659
Title: Anterograde effects of a single electroconvulsive shock on inhibitory avoidance and on cued fear conditioning
Authors: Oliveira, Maria Gabriela Menezes de [UNIFESP]
Bueno, Orlando Francisco Amodeo [UNIFESP]
Gugliano, Eric Boragan [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: electroconvulsive shock
memory
cued fear conditioning
inhibitory avoidance
anxiolytic effect
analgesic effect
Issue Date: 1-Aug-1998
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 8, p. 1091-1094, 1998.
Abstract: A single electroconvulsive shock (ECS) or a sham ECS was administered to male 3-4-month-old Wistar rats 1, 2, and 4 h before training in an inhibitory avoidance test and in cued classical fear conditioning (measured by means of freezing time in a new environment). ECS impaired inhibitory avoidance at all times and, at 1 or 2 h before training, reduced freezing time before and after re-presentation of the ECS. These results are interpreted as a transient conditioned stimulus (CS)-induced anxiolytic or analgesic effect lasting about 2 h after a single treatment, in addition to the known amnesic effect of the stimulus. This suggests that the effect of anterograde learning impairment is demonstrated unequivocally only when the analgesic/anxiolytic effect is over (about 4 h after ECS administration) and that this impairment of learning is selective, affecting inhibitory avoidance but not classical fear conditioning to a discrete stimulus.
URI: http://repositorio.unifesp.br/handle/11600/659
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/S0100-879X1998000800009
Appears in Collections:Em verificação - Geral

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