Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/6292
Title: Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
Authors: Lobo, Clarisse Lopes de Castro
Cançado, Rodolfo Delfini
Leite, Ana Claudia Celestino Bezerra
Anjos, Ana Claudia Mendonça dos
Pinto, Ana Cristina Silva
Matta, Andre Palma da Cunha
Silva, Célia Maria
Silva, Gisele Sampaio [UNIFESP]
Friedrisch, João Ricardo
Braga, Josefina Aparecida Pellegrini [UNIFESP]
Lange, Marcos Christiano
Figueiredo, Maria Stella [UNIFESP]
Rugani, Marília Álvares
Veloso, Orlando
Moura, Patrícia Gomes
Cortez, Paulo Ivo
Adams, Robert
Gualandro, Sandra Fátima Menosi
Castilho, Shirley Lopes de
Thomé, Ursula
Zetola, Viviane Flumignan
Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti
Faculdade de Ciências Médicas da Santa Casa de São Paulo
Fundação de Hematologia e Hemoterapia de Pernambuco
Universidade de São Paulo (USP)
Fundação Hemocentro
Fundação Centro de Hematologia e Hemoterapia de Minas Gerais
UFRGS Hospital de Clínicas de Porto Alegre Serviço de Hematologia e Transplante de Medula Óssea
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Paraná Hospital de Clínicas Serviço de Neurologia
Ecodopler Laboratório
Universidade Federal do Rio de Janeiro Instituto de Puericultura e Pediatria Martagão Gesteira
Medical University of South Carolina
Keywords: Ultrasonography, doppler, transcranial
Anemia, sickle cell
Hemoglobin
Stroke
Child
Adolescent
Guideline
Issue Date: 1-Feb-2011
Publisher: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Citation: Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, v. 33, n. 1, p. 43-48, 2011.
Abstract: BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients.
URI: http://repositorio.unifesp.br/handle/11600/6292
ISSN: 1516-8484
Other Identifiers: http://dx.doi.org/10.5581/1516-8484.20110014
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