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Title: Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
Authors: Beirão, Elisa Maria
Furtado, Juvencio Jose Duailibe
Girardello, Raquel [UNIFESP]
Ferreira Filho, Heli
Gales, Ana Cristina [UNIFESP]
Hospital Heliópolis
Hospital Heliópolis Department of Infectious Diseases
Universidade Federal de São Paulo (UNIFESP)
Hospital Heliópolis Microbiology Laboratory
Keywords: Klebsiella pneumonia
hospital infection
Issue Date: 1-Feb-2011
Publisher: Brazilian Society of Infectious Diseases
Citation: Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 15, n. 1, p. 69-73, 2011.
Abstract: In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.
ISSN: 1413-8670
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