Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/57881
Title: GLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTREN
Authors: Hirai Nascimento, Priscilla Carneiro [UNIFESP]
Kobayashi, Elsa Yoko [UNIFESP]
de Saboya Lenzi, Luiz Guilherme [UNIFESP]
Gomes dos Santos, Joao Baptista [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Faloppa, Flavio [UNIFESP]
Keywords: Dupuytren contracture
Glycosaminoglycans
Proteoglycans
Fascia
Issue Date: 2016
Publisher: Atha Comunicacao & Editora
Citation: Acta Ortopedica Brasileira. Sao Paulo Sp, v. 24, n. 2, p. 98-101, 2016.
Abstract: Objective: To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD). Methods: This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with incision type Brunner or McCash were evaluated by electrophoresis for identification of GAGs. The quantification was carried out by immunofluorescence and dosage of proteins for different types of glycosaminoglycans. The results were expressed in percentage and statistically evaluated. Results: A significant increase was observed through eletrophoresis in GAGs, as compared to the control (p<0.05). Immunofluorescence of hyaluronic acid was reduced (23 times) when compared to the control (p<0.0001). Conclusion: An increase of sulfated GAGs in Dupuytren's disease, mainly dermatan sulfate, was evident from our results, as well as a pronounced decrease of hyaluronic acid in the palmar aponeurosis from the same patients.
URI: https://repositorio.unifesp.br/handle/11600/57881
ISSN: 1413-7852
Other Identifiers: http://dx.doi.org/10.1590/1413-785220162402154342
Appears in Collections:Artigo

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