Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/57629
Title: Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children
Authors: Louzada Strufaldi, Maria Wany [UNIFESP]
Suano de Souza, Fabiola Isabel [UNIFESP]
Puccini, Rosana Fiorini [UNIFESP]
Pinho Franco, Maria do Carmo [UNIFESP]
Keywords: dyslipidemias
cardiovascular diseases
child
primary prevention
Issue Date: 2016
Publisher: Assoc Medica Brasileira
Citation: Revista Da Associacao Medica Brasileira. Sao Paulo, v. 62, n. 4, p. 347-352, 2016.
Abstract: Objective: To describe the values of non-HDL cholesterol (NHDL-c) and the frequency of a family history of early cardiovascular disease (family HCVD) in healthy prepubescent children. Analyze the association between NHDL-c and family HCVD, and possible associations with other risk factors for cardiovascular disease (CVD). Method: Cross-sectional study including 269 prepubescent (aged 6-10 years) schoolchildren with a normal body mass index (+1SD<BMI>-2SD). Data collected: Family HCVD
weight and height, waist circumference and systemic blood pressure
lipid profile (total cholesterol TC, HDL-c, triglycerides and LDL-c), NHDL-c calculation (CT-HDL-c, cut-off = 145 mg/dL) and insulin resistance (HOMA-IR). Results: High levels were found for NHDL-c in 10 (3.7%) of these schoolchildren, and family early HCVD was found in 46 (17.1%) of them. There was a weak association between family HCVD and NHDL-c (Cramer's-V-test = 0.120
p=0.050). Among the children with NHDL-c >= 145 mg/dL, 4 (40%) have family HCVD. The presence of family HCVD was not associated with the variables being studied. The variables independently associated with NHDL-c = 145 mg/dL were: HOMA-IR (OR=1.7
95CI 1.1-2.6) and diastolic blood pressure (OR=1.1
95CI 1.02-1.2). Conclusion: NHDL-c values were associated with blood pressure and insulin resistance. Family HCVD was not associated with other classic risk factors for CVD, even though the frequency found was five times higher than that of high NHDL-c.
URI: https://repositorio.unifesp.br/handle/11600/57629
ISSN: 0104-4230
Other Identifiers: http://dx.doi.org/10.1590/1806-9282.62.04.347
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Artigo

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