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Title: Biflorin induces cytotoxicity by DNA interaction in genetically different human melanoma cell lines
Authors: Lima Ralph, Ana Carolina
Calcagno, Danielle Queiroz
da Silva Souza, Luciana Gregorio
Gomes de Lemos, Telma Leda
Montenegro, Raquel Carvalho
Cardoso Smith, Marilia de Arruda [UNIFESP]
de Vasconcellos, Marne Carvalho
Keywords: Biflorin
Human melanoma
Cell cycle progression
Repair genes
Replication genes
Issue Date: 2016
Publisher: Pergamon-Elsevier Science Ltd
Citation: Toxicology In Vitro. Oxford, v. 34, p. 237-245, 2016.
Abstract: Cancer is a public health problem and the second leading cause of death worldwide. The incidence of cutaneous melanoma has been notably increasing, resulting in high aggressiveness and poor survival rates. Taking into account the antitumor activity of biflorin, a substance isolated from Capraria biflora L roots that is cytotoxic in vitro and in vivo, this study aimed to demonstrate the action of biflorin against three established human melanoma cell lines that recapitulate the molecular landscape of the disease in terms of genetic alterations and mutations, such as the TP53, NRAS and BRAF genes. The results presented here indicate that biflorin reduces the viability of melanoma cell lines by DNA interactions. Biflorin causes single and double DNA strand breaks, consequently inhibiting cell cycle progression, replication and DNA repair and promoting apoptosis. Our data suggest that biflorin could be considered as a future therapeutic option for managing melanoma. (C) 2016 Elsevier Ltd. All rights reserved.
ISSN: 0887-2333
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