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|Title:||Frequency of BKC-1-Producing Klebsiella Species Isolates|
|Authors:||Martins, Willames M. B. S. [UNIFESP]|
Nicoletti, Adriana G. [UNIFESP]
Santos, Silvia R.
Sampaio, Jorge L. M.
Gales, Ana C. [UNIFESP]
|Publisher:||Amer Soc Microbiology|
|Citation:||Antimicrobial Agents And Chemotherapy. Washington, v. 60, n. 8, p. 5044-5046, 2016.|
|Abstract:||BKC-1 is a new class A serine carbapenemase that was recently identified in Klebsiella pneumoniae clinical isolates. The principal objective of this study was to evaluate the frequency of bla(BKC-1) by testing a collection of Klebsiella isolates. Only 2 of 635 Klebsiella isolates (0.3%) carried bla(BKC-1). The two BKC-1-producing isolates belonged to clonal complex 442 and possessed identical pulsed-field gel electrophoresis patterns. The blaBKC-1 gene was inserted into a 10-kb plasmid that was identical to the previously reported plasmid, p60136. The BKC-producing K. pneumoniae isolates presented also possessed other mechanisms for beta-lactam resistance, such as genes encoding extended-spectrum beta-lactamases and mutations in the genes ompK35 and ompK36, encoding the major porins.|
|Appears in Collections:||Artigo|
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