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dc.contributor.authorRasmussen, Lucas Trevizani [UNIFESP]
dc.contributor.authorLábio, Roger Willian de
dc.contributor.authorGatti, Luciano Lobo
dc.contributor.authorSilva, Luiz Carlos da
dc.contributor.authorQueiroz, Valdeir Fagundes de
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.authorPayão, Spencer Luiz Marques [UNIFESP]
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 105, n. 3, p. 326-330, 2010.
dc.description.abstractHelicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the stomach, which can sometimes occur following treatment of an H. pylori infection. The objectives of this paper were (i) to determine the presence of H. pylori in the oral cavity and (ii) to examine the relationship between oral H. pylori and subsequent gastritis. Gastric biopsies, saliva samples and dental plaques were obtained from 78 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori using polymerase chain reaction and Southern blotting methods. Persons with gastritis were frequently positive for H. pylori in their stomachs (p < 0.0001) and there was a statistically significant correlation between the presence of H. pylori in gastric biopsies and the oral cavity (p < 0.0001). Our results suggest a relationship between gastric infection and the presence of this bacterium in the oral cavity. Despite this, H. pylori were present in the oral cavity with variable distribution between saliva and dental plaques, suggesting the existence of a reservoir for the species and a potential association with gastric reinfection.en
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsAcesso aberto
dc.subjectHelicobacter pylorien
dc.subjectoral infectionen
dc.subjectdental plaqueen
dc.titleHelicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patientsen
dc.contributor.institutionUniversidade do Sagrado Coração
dc.contributor.institutionFaculdade de Medicina de Marília Hemocentro
dc.contributor.institutionFaculdades Integradas de Ourinhos
dc.contributor.institutionFaculdade de Medicina de Marília
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade do Sagrado Coração
dc.description.affiliationFaculdade de Medicina de Marília Hemocentro
dc.description.affiliationFaculdades Integradas de Ourinhos
dc.description.affiliationFaculdade de Medicina de Marília
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Morfologia
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Morfologia
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