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Title: Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients
Authors: Rasmussen, Lucas Trevizani [UNIFESP]
Lábio, Roger Willian de
Gatti, Luciano Lobo
Silva, Luiz Carlos da
Queiroz, Valdeir Fagundes de
Smith, Marilia de Arruda Cardoso [UNIFESP]
Payão, Spencer Luiz Marques [UNIFESP]
Universidade do Sagrado Coração
Faculdade de Medicina de Marília Hemocentro
Faculdades Integradas de Ourinhos
Faculdade de Medicina de Marília
Universidade Federal de São Paulo (UNIFESP)
Keywords: Helicobacter pylori
oral infection
dental plaque
Issue Date: 1-May-2010
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Citation: Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 105, n. 3, p. 326-330, 2010.
Abstract: Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the stomach, which can sometimes occur following treatment of an H. pylori infection. The objectives of this paper were (i) to determine the presence of H. pylori in the oral cavity and (ii) to examine the relationship between oral H. pylori and subsequent gastritis. Gastric biopsies, saliva samples and dental plaques were obtained from 78 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori using polymerase chain reaction and Southern blotting methods. Persons with gastritis were frequently positive for H. pylori in their stomachs (p < 0.0001) and there was a statistically significant correlation between the presence of H. pylori in gastric biopsies and the oral cavity (p < 0.0001). Our results suggest a relationship between gastric infection and the presence of this bacterium in the oral cavity. Despite this, H. pylori were present in the oral cavity with variable distribution between saliva and dental plaques, suggesting the existence of a reservoir for the species and a potential association with gastric reinfection.
ISSN: 0074-0276
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