Please use this identifier to cite or link to this item:
Title: Intra-articular injection in patients with juvenile idiopathic arthritis: factors associated with a good response
Other Titles: Infiltração intra-articular em pacientes com artrite idiopática juvenil: fatores associados à boa resposta
Authors: Cunha, Ana Luiza Garcia [UNIFESP]
Silva, Vanessa Bugni Miotto e [UNIFESP]
Osaku, Fabiane Mitie [UNIFESP]
Niemxeski, Luisa Brasil [UNIFESP]
Furtado, Rita Nely Vilar [UNIFESP]
Natour, Jamil [UNIFESP]
Sande, Maria Teresa de [UNIFESP]
Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
Keywords: Intra-articular injection
Juvenile idiopathic arthritis
Triamcinolone hexacetonide
Treatment and uveitisa
Infiltração intra-articular
Artrite idiopática juvenil
Hexacetonido de triancinolona
Tratamento e uveíte
Issue Date: 2016
Publisher: Elsevier Science Inc
Citation: Revista Brasileira De Reumatologia. New York, v. 56, n. 6, p. 490-496, 2016.
Abstract: Introduction: Intra-articular injection of corticosteroids (IIC) for treatment of patients with juvenile idiopathic arthritis (JIA) is increasingly used in Pediatric Rheumatology. Objectives: To describe the clinical course of patients undergoing IIC in our Pediatric Rheumatology Unit. Methods: Retrospective study of patients with JIA undergoing IIC from January 2008 to December 2012, with a minimum follow-up of six months after the injection. Good response to IIC was set as the presence of inactivity on the infiltrated joint by at least six months. Results: Eighty-eight patients underwent a total of 165 IICs. Of these, 75% were girls and 35.2% had persistent oligoarticular JIA. The mean age at diagnosis was 6.8 years, and when IIC was carried out, 12.2 years. Regarding patients, younger age at diagnosis (p = 0.037) and the occurrence of uveitis in the course of the disease (p = 0.015) were associated with good response to IIC. From 165 IICs, 63% had a good response and joints remained inactive for a median of 18.1 months. The type of joint injection (p =0.001), lesser values stated in the overall visual analog scale by the physician (p = 0.015) and by parents/patient (p = 0.01) have been associated with a good response to IIC. Nine adverse events (5.4%) were observed. Conclusion: In our study, more than half of the joints showed a good response to IIC. Younger patients at diagnosis and uveitis during the course of the disease had good response to IIC. Knees, wrists and elbows were the joints that best responded to IIC. IIC proved to be a safe procedure. (C) 2016 Elsevier Editora Ltda.
Introdução: A infiltração intra-articular de corticosteroides (IIC) para tratamento de pacientes com artrite idiopática juvenil (AIJ) é cada vez mais usada em reumatologia pediátrica. Objetivos: Descrever a evolução clínica dos pacientes submetidos à IIC em nosso setor de reumatologia pediátrica. Métodos: Estudo retrospectivo de pacientes com AIJ submetidos à IIC de janeiro/2008 a dezembro/2012, com seguimento mínimo de seis meses após a infiltração. Boa resposta à IIC foi definida como inatividade na articulação infiltrada por, no mínimo, seis meses. Resultados: Foram submetidos a 88 pacientes a 165 IICs. Desses, 75% eram meninas e 35,2% apresentavam AIJ oligoarticular persistente. A média de idade ao diagnóstico foi de 6,8 anos e à IIC de 12,2 anos. Em relação aos pacientes, a menor idade ao diagnóstico (p = 0,037) e a ocorrência de uveíte no curso da doença (p = 0,015) foram associados à boa resposta à IIC. Das 165 IICs, 63% apresentaram boa resposta e as articulações permaneceram inativas por um tempo médio de 18,1 meses. O tipo de articulação infiltrada (p = 0,001), menores valores na escala visual analógica global do médico (p = 0,015) e dos pais/paciente (p = 0,01) foram associados a uma boa resposta à IIC. Nove efeitos adversos (5,4%) foram observados. Conclusão: Em nosso estudo, mais da metade das articulações mostrou boa resposta à IIC. Os pacientes com menor idade ao diagnóstico e uveíte durante o curso da doença tiveram boa resposta à IIC. Os joelhos, punhos e cotovelos foram as articulações que mais bem responderam à IIC. A IIC mostrou ser um procedimento seguro.
ISSN: 0482-5004
Other Identifiers:
Appears in Collections:Artigo

Files in This Item:
File Description SizeFormat 
S0482-50042016000600490-en.pdf300.36 kBAdobe PDFView/Open
S0482-50042016000600490-pt.pdf547.27 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.