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Title: A Current Snapshot of Common Genomic Variants Contribution in Psychiatric Disorders
Authors: Santoro, Marcos Leite [UNIFESP]
Moretti, Patricia N. [UNIFESP]
Pellegrino, Renata
Gadelha, Ary [UNIFESP]
Abilio, Vanessa Costhek [UNIFESP]
Hayashi, Mirian Akemi Furuie [UNIFESP]
Belangero, Sintia Iole [UNIFESP]
Hakonarson, Hakon
Keywords: GWAS
polygenic risk score
psychiatric disorder
Issue Date: 2016
Publisher: Wiley
Citation: American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. Hoboken, v. 171, n. 8, p. 997-1005, 2016.
Abstract: In the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polygenic risk score (PRS) promoted an additional tool for identification and evaluation the genetic risk quantitatively in PDs. This concept review presents the state of the art GWAS analysis and PRS focusing on the genetic underpinnings of PDs. (C) 2016 Wiley Periodicals, Inc.
ISSN: 1552-4841
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