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Title: Clinical trial endpoints for optical coherence tomography angiography in neovascular age-related macular degeneration
Authors: Cole, Emily D.
Ferrara, Daniela
Novais, Eduardo A.
Louzada, Ricardo Nogueira [UNIFESP]
Waheed, Nadia K.
Keywords: optical coherence tomography
optical coherence tomography angiography
neovascular age-related macular degeneration
Issue Date: 2016
Publisher: Lippincott Williams & Wilkins
Citation: Retina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 36, n. 12, p. S83-S92, 2016.
Abstract: Purpose: To describe qualitative and quantitative optical coherence tomography (OCT) angiography (OCTA) parameters for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and their applicability as potential clinical trial endpoints. Methods: A review of current literature related to the topic of OCTA and AMD. Results: There are a number of promising OCTA parameters that can be used to diagnose the presence of CNV and to monitor the activity and progression of the lesion, pre- and post-treatment morphological characteristics, CNV dimensions, and automated quantitative parameters such as vessel density. Conclusion: The OCTA parameters described in this review have promise for the future development of clinical trial endpoints, but require further validation before they can be widely used.
ISSN: 0275-004X
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Appears in Collections:Artigo

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