Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/55925
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dc.contributor.authorFidelix, Tania [UNIFESP]
dc.contributor.authorCzapkowski, Adriano [UNIFESP]
dc.contributor.authorAzjen, Sergio [UNIFESP]
dc.contributor.authorAndriolo, Adagmar [UNIFESP]
dc.contributor.authorHorvath Neto, Pedro [UNIFESP]
dc.contributor.authorTrevisani, Virgínia Fernandes Moça [UNIFESP]
dc.date.accessioned2020-07-20T16:31:23Z-
dc.date.available2020-07-20T16:31:23Z-
dc.date.issued2018
dc.identifierhttp://dx.doi.org/10.1007/s10067-017-3898-9
dc.identifier.citationClinical Rheumatology. London, v. 37, n. 3, p. 729-736, 2018.
dc.identifier.issn0770-3198
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55925-
dc.description.abstractTo evaluate the effectiveness of low-level laser therapy (LLLT) in the treatment of xerostomia in primary Sjogren's syndrome (SS), a randomized clinical trial of patients with dry mouth symptoms associated with primary SS receiving care at a university hospital was conducted. Sixty-six patients were randomly assigned with a 1:1 allocation ratio to receive LLLT (laser group, n = 33) or placebo treatment (placebo group, n = 33). Patients in the laser group received LLLT twice a week for 6 weeks, for a total of 12 treatment sessions. Laser irradiation was performed with an aluminum-gallium-arsenide laser diode at a wavelength of 808 nm, 100-mW output power, and energy density of 4.0 J/cm(2) per irradiation point per session. Placebo treatment was performed following the same protocol used for irradiated patients and using the same laser device to mimic a real irradiation, but with no active laser emission and the tip of the laser probe covered with aluminum foil. The outcomes of interest were xerostomia inventory scores, salivary flow rate, salivary beta-2 microglobulin levels, and salivary sodium and chlorine concentrations. Patients in both groups showed no improvement in xerostomia. Likewise, there was no significant improvement in xerostomia inventory scores (p = 0.301) or salivary flow rate (p = 0.643) in either group. There was no difference in salivary beta-2 microglobulin levels, sodium concentration, and chlorine concentration before and after intervention or between the two groups. The LLLT protocol used in this study effected no improvement in xerostomia or salivary flow rate in patients with primary SS. ClinicalTrials.gov Identifier: NCT02066896.en
dc.format.extent729-736
dc.language.isoeng
dc.publisherSpringer London Ltd
dc.relation.ispartofClinical Rheumatology
dc.rightsAcesso restrito
dc.subjectLow-level laser therapyen
dc.subjectSaliva biochemistryen
dc.subjectSjogren's syndromeen
dc.subjectXerostomiaen
dc.titleLow-level laser therapy for xerostomia in primary Sjogren's syndrome: a randomized trialen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Evidence Based Hlth, Rua Barao do Triunfo 156-232, BR-04602000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Radiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Lab Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Evidence Based Hlth, Rua Barao do Triunfo 156-232, BR-04602000 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Radiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Lab Med, Sao Paulo, SP, Brazil
dc.identifier.doi10.1007/s10067-017-3898-9
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000426714500020
dc.coverageLondon
dc.citation.volumev. 37
dc.citation.issue3
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Artigo

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