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https://repositorio.unifesp.br/handle/11600/55892| Title: | The Association of Serum 25-Hydroxyvitamin D With Biomarkers of Hemolysis in Pediatric Patients With Sickle Cell Disease |
| Authors: | Adegoke, Samuel Ademola [UNIFESP] Braga, Josefina Aparecida Pellegrini [UNIFESP] Adekile, Adekunle D. Figueiredo, Maria Stella [UNIFESP] |
| Keywords: | biomarkers hemolysis pediatric sickle cell disease 25-hydroxyvitamin D |
| Issue Date: | 2018 |
| Publisher: | Lippincott Williams & Wilkins |
| Citation: | Journal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 2, p. 159-162, 2018. |
| Abstract: | Although vitamin D deficiency (VDD) has been linked to anemia among sickle cell disease (SCD), its relationship with hemolysis is unclear. Serum 25-hydroxyvitamin D and biomarkers of hemolysis (hemoglobin [Hb]/hematocrit, reticulocyte percentage, absolute reticulocyte, and lactate dehydrogenase [LDH] levels) in 36 hydroxyurea-naive SCD children were quantified. Correlations were significantly positive with Hb/hematocrit (r=0.40, P=0.017 r=0.45, P=0.006, respectively) inverse with reticulocyte percentage, absolute reticulocyte, and LDH (r=-0.44, P=0.008 r=-0.47, P=0.007 r=-0.45, P=0.007, respectively). In VDD groups, Hb was lower (P=0.014), reticulocyte counts and LDH were higher (P=0.047 and 0.003, respectively). Serum 25-hydroxyvitamin D correlated with biomarkers of hemolysis in SCD and VDD may play a role in SCD pathogenesis. |
| URI: | https://repositorio.unifesp.br/handle/11600/55892 |
| ISSN: | 1077-4114 |
| Other Identifiers: | http://dx.doi.org/10.1097/MPH.0000000000000783 |
| Appears in Collections: | Artigo Artigo |
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