Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/54884
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dc.contributor.authorOliveira, V. [UNIFESP]
dc.contributor.authorSilva Junior, S. D.
dc.contributor.authorde Carvalho, M. H. C.
dc.contributor.authorAkamine, E. H.
dc.contributor.authorMichelini, L. C.
dc.contributor.authorFranco, M. C. [UNIFESP]
dc.date.accessioned2020-07-17T14:02:35Z-
dc.date.available2020-07-17T14:02:35Z-
dc.date.issued2017
dc.identifierhttp://dx.doi.org/10.1017/S2040174416000714
dc.identifier.citationJournal Of Developmental Origins Of Health And Disease. Cambridge, v. 8, n. 2, p. 236-243, 2017.
dc.identifier.issn2040-1744
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54884-
dc.description.abstractIt has been demonstrated that intrauterine growth restriction (IUGR) can program increase cardiometabolic risk. There are also evidences of the correlation between IUGR with low-grade inflammation and, thus can contribute to development of several cardiometabolic comorbidities. Therefore, we investigated the influence of IUGR on circulating mitochondrial DNA (mtDNA)/Toll-like receptor 9 (TLR9) and TNF-alpha expression in adult offspring. Considering that the aerobic training has anti-inflammatory actions, we also investigated whether aerobic training would improve these inflammatory factors. Pregnant Wistar rats received ad libitum or 50% of ad libitum diet throughout gestation. At 8 weeks of age, male offspring from both groups were randomly assigned to control, trained control, restricted and trained restricted. Aerobic training protocol was performed on a treadmill and after that, we evaluated circulating mtDNA, cardiac protein expression of TLR9, plasma and cardiac TNF-levels, and left ventricle (LV) mass. We found that IUGR promoted an increase in the circulating mtDNA, TLR9 expression and plasma TNF-alpha levels. Further, our results revealed that aerobic training can restore mtDNA/TLR9 content and plasma levels of TNF-alpha among restricted rats. The cardiac TNF-alpha content and LV mass were not influenced either by IUGR or aerobic training. In conclusion, IUGR can program mtDNA/TLR9 content, which may lead to high levels of TNF-alpha. However, aerobic training was able to normalize these alterations. These findings evidenced that the association of IUGR and aerobic training seems to exert an important interaction effect regarding pro-inflammatory condition and, aerobic training may be used as a strategy to reduce deleterious adaptations in IUGR offspring.en
dc.description.sponsorshipFAPESP ( Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil)
dc.format.extent236-243
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofJournal Of Developmental Origins Of Health And Disease
dc.rightsAcesso restrito
dc.subjectaerobic trainingen
dc.subjectfetal programmingen
dc.subjecthearten
dc.subjectintrauterine growth restrictionen
dc.titleIntrauterine growth restriction increases circulating mitochondrial DNA and Toll-like receptor 9 expression in adult offspring: could aerobic training counteract these adaptations?en
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo, Div Nephrol, Sch Med, Rua Botucatu,703, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Physiol Dept, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Pharmacol Dept, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sch Med, Physiol Dept, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Nephrol, Sch Med, Rua Botucatu,703, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med, Physiol Dept, Sao Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2013/03139-0
dc.description.sponsorshipIDFAPESP: 2013/00311-6
dc.identifier.doi10.1017/S2040174416000714
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000395508600012
dc.coverageCambridge
dc.citation.volume8
dc.citation.issue2
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Artigo

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