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Title: Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
Authors: Ferreira Filho, Celso [UNIFESP]
Abreu, Luiz Carlos de
Valenti, Vitor Engrácia [UNIFESP]
Ferreira, Marcelo
Meneghini, Adriano
Silveira, José Alexandre
Perez Riera, Andrés Ricardo [UNIFESP]
Colombari, Eduardo [UNIFESP]
Murad, Neif
Santos-Silva, Paulo Roberto
Silva, Lovian José Henrique Pereira da
Vanderlei, Luiz Carlos Marques
Carvalho, Tatiana Dias de [UNIFESP]
Ferreira, Celso [UNIFESP]
Faculdade de Medicina do ABC Disciplina de Cardiologia Departamento de Clínica Médica
Faculdade de Medicina do ABC Departamento de Morfologia e Fisiologia
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual Paulista (UNESP)
Keywords: Hypertrophy
Left ventricle hypertension
Issue Date: 1-Jan-2010
Publisher: Faculdade de Medicina / USP
Citation: Clinics. Faculdade de Medicina / USP, v. 65, n. 7, p. 723-728, 2010.
Abstract: OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.
ISSN: 1807-5932
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