Please use this identifier to cite or link to this item:
|Title:||Anti-ribosomal P antibody: a multicenter study in childhood-onset systemic lupus erythematosus patients|
|Authors:||Valoes, C. C. M.|
Molinari, B. C.
Pitta, A. C. G.
Gormezano, N. W. S.
Farhat, S. C. L.
Sallum, A. M. E.
Sakamoto, A. P. [UNIFESP]
Terreri, M. T. [UNIFESP]
Pereira, R. M. R.
Magalhaes, C. S.
Ferreira, J. C. O. A.
Barbosa, C. M.
Gomes, F. H.
Silva, C. A.
|Keywords:||Systemic lupus erythematosus|
anti-ribosomal P protein antibodies
autoimmune hemolytic anemia
|Publisher:||Sage Publications Ltd|
|Citation:||Lupus. London, v. 26, n. 5, p. 484-489, 2017.|
|Abstract:||Objectives: Anti-ribosomal P protein (anti-P) autoantibodies are highly specific for systemic lupus erythematosus (SLE). However, the evaluation of this autoantibody in childhood-onset SLE (cSLE) populations has been limited to a few small series, hampering the interpretation of the clinical and laboratorial associations. Therefore, the objective of this multicenter cohort study was to evaluate demographic, clinical/laboratorial features, and disease damage score in cSLE patients with and without the presence of anti-P antibody. Methods: This was a retrospective multicenter study performed in 10 pediatric rheumatology services of Sao Paulo state, Brazil. Anti-P antibodies were measured by ELISA in 228 cSLE patients. Results: Anti-P antibodies were observed in 61/228 (27%) cSLE patients. Frequencies of cumulative lymphadenopathy (29% vs. 15%, p = 0.014), acute confusional state (13% vs. 5%, p = 0.041), mood disorder (18% vs. 8%, p = 0.041), autoimmune hemolytic anemia (34% vs. 15%, p = 0.001), as well as presence of anti-Sm (67% vs. 40%, p = 0.001), anti-RNP (39% vs. 21%, p = 0.012) and anti-Ro/SSA antibodies (43% vs. 25%, p = 0.016) were significantly higher in cSLE patients with anti-P antibodies compared to those without these autoantibodies. A multiple regression model revealed that anti-P antibodies were associated with autoimmune hemolytic anemia (odds ratio (OR) = 2.758, 95% confidence interval (CI): 1.304-5.833, p = 0.008) and anti-Sm antibody (OR = 2.719, 95% CI: 1.365-5.418, p = 0.004). The SLICC/ACR damage index was comparable in patients with and without anti-P antibodies (p = 0.780). Conclusions: The novel association of anti-P antibodies and autoimmune hemolytic anemia was evidenced in cSLE patients and further studies are necessary to determine if anti-P titers may vary with this hematological manifestation.|
|Appears in Collections:||Artigo|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.