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dc.contributor.authorMansur, Rodrigo B. [UNIFESP]
dc.contributor.authorCunha, Graccielle R. [UNIFESP]
dc.contributor.authorAsevedo, Elson [UNIFESP]
dc.contributor.authorZugman, Andre [UNIFESP]
dc.contributor.authorRios, Adiel C. [UNIFESP]
dc.contributor.authorSalum, Giovanni A.
dc.contributor.authorPan, Pedro M. [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorLevandowski, Mateus L.
dc.contributor.authorBelangero, Sintia I. [UNIFESP]
dc.contributor.authorManfro, Gisele G. [UNIFESP]
dc.contributor.authorStertz, Laura
dc.contributor.authorKauer-Sant'anna, Marcia
dc.contributor.authorMiguel, Euripedes C.
dc.contributor.authorBressan, Rodrigo A. [UNIFESP]
dc.contributor.authorMari, Jair J. [UNIFESP]
dc.contributor.authorGrassi-Oliveira, Rodrigo [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.identifier.citationEuropean Child & Adolescent Psychiatry. New York, v. 26, n. 5, p. 521-529, 2017.
dc.description.abstractReplicated evidence indicates that perinatal complications are associated with increased markers of oxidative stress and with mental health problems in children. However, there are fewer reports on the impact of perinatal complications in later phases of development. We aimed to investigate the estimated effects of perinatal complications on levels of lipid peroxidation and on psychopathology in children and adolescents. The study is part of the High Risk Cohort Study for Psychiatric Disorders the population was composed by 554 students, 6-14 years of age. Serum levels of malondialdehyde, a product of lipid peroxidation, were measured by the TBARS method. A household interview with parents and caregivers was conducted and included inquiries about perinatal history, the Child Behavior Checklist (CBCL), and parent's evaluation, using the Mini International Psychiatric Interview (MINI). We created a cumulative risk index, conceptualized as each individual's cumulative exposure to perinatal complications. Results indicate that perinatal complications were associated with higher levels of TBARS. After adjusting for age, gender, socio-economic status, CBCL total problems score, parental psychopathology, and childhood maltreatment, children exposed to 3 or more perinatal complications had an 26.9% (95% CI 9.9%, 46.6%) increase in TBARS levels, relative to the unexposed group. Exploratory mediation analysis indicated that TBARS levels partially mediated the association between perinatal complications and externalizing problems. In conclusion, an adverse intrauterine and/or early life environment, as proxied by the cumulative exposure to perinatal complications, was independently associated with higher levels of lipid peroxidation in children and adolescents.en
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.relation.ispartofEuropean Child & Adolescent Psychiatry
dc.rightsAcesso restrito
dc.subjectOxidative stressen
dc.subjectLipid peroxidationen
dc.subjectPerinatal complicationsen
dc.subjectAdverse early life environmenten
dc.titlePerinatal complications, lipid peroxidation, and mental health problems in a large community pediatric sampleen
dc.description.affiliationCNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, PRISMA Program Recognit & Intervent Individuals A, Sao Paulo, Brazil
dc.description.affiliationUniv Toronto, Univ Hlth Network, MDPU, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Inst Biomed Res, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Texas Hlth Sci Ctr Houston, Ctr Translat Psychiat, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
dc.description.affiliationUniv Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, PRISMA Program Recognit & Intervent Individuals A, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.coverageNew York
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