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Title: Shorter leukocyte telomere length in patients at ultra high risk for psychosis
Authors: Maurya, Pawan Kumar [UNIFESP]
Rizzo, Lucas Bortolotto [UNIFESP]
Xavier, Gabriela [UNIFESP]
Tempaku, Priscila Farias
Zeni-Graiff, Maiara
Santoro, Marcos L. [UNIFESP]
Mazzotti, Diego Robles
Zugman, Andre
Pan, Pedro
Noto, Cristiano [UNIFESP]
Maes, Michael
Asevedo, Elson
Mansur, Rodrigo B.
Cunha, Graccielle R. [UNIFESP]
Gadelha, Ary
Bressan, Rodrigo A. [UNIFESP]
Belangero, Sintia Iole [UNIFESP]
Brietzke, Elisa
Keywords: Ultra-high risk
Issue Date: 2017
Publisher: Elsevier Science Bv
Citation: European Neuropsychopharmacology. Amsterdam, v. 27, n. 5, p. 538-542, 2017.
Abstract: Telomere length attrition has been demonstrated in schizophrenia but not in individuals in ultra high risk (UHR) for psychosis. The present study aimed to compare the leukocyte telomere length (TL) between patients at UHR for psychosis and healthy controls (HC). Twenty-two participants with UHR and 88 HC were enrolled in this study. Telomere lengths were determined using a multiplex qPCR assay. After adjustment for age, sex, ethnicity, and education, patients in UHR, compared with HC groups, had shorter telomere length (RR: 0.929, p=0.031). Shorter leukocyte telomere length in UHR could represent early signs of accelerated aging in this population. (C) 2017 Elsevier B.V. and ECNP. All rights reserved.
ISSN: 0924-977X
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