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Title: MYC Amplification as a Predictive Factor of Complete Pathologic Response to Docetaxel-based Neoadjuvant Chemotherapy for Breast Cancer
Authors: Lins Pereira, Cynthia Brito
Leal, Mariana Ferreira [UNIFESP]
Furquim Werneck Abdelhay, Eliana Saul
Demachki, Samia
Assumpcao, Paulo Pimentel
de Souza, Mirian Carvalho
Moreira-Nunes, Caroline Aquino
da Silva Tanaka, Adriana Michiko
Smith, Marilia Cardoso [UNIFESP]
Burbano, Rommel Rodriguez
Keywords: Breast cancer
Gene amplification
Pathologic response
Issue Date: 2017
Publisher: Cig Media Group, Lp
Citation: Clinical Breast Cancer. Dallas, v. 17, n. 3, p. 188-194, 2017.
Abstract: The identification of biomarkers may help in the prediction of response to neoadjuvant therapies. The role of Ki67, hormone receptors, HER2, MYC, and KRAS as predictor factors of response to anthracycline-cyclophosphamide followed by taxane neoadjuvant chemotherapy was investigated in 51 patients with breast cancer. MYC amplification analysis may help in the identification of patients that better respond to this treatment. Background: Neoadjuvant chemotherapy is a standard treatment for stage II and III breast cancer. The identification of biomarkers that may help in the prediction of response to neoadjuvant therapies is necessary for a more precise definition of the best drug or drug combination to induce a better response. Material and Methods: We assessed the role of Ki67, hormone receptors expression, HER2, MYC genes and their protein status, and KRAS codon 12 mutations as predictor factors of pathologic response to anthracycline-cyclophosphamide (AC) followed by taxane docetaxel (T) neoadjuvant chemotherapy (AC+T regimen) in 51 patients with invasive ductal breast cancer. Results: After neoadjuvant chemotherapy, 82.4% of patients showed pathologic partial response, with only 9.8% showing pathologic complete response. In multivariate analysis, MYC immunoreactivity and high MYC gain defined as MYC/nucleus >= 5 were significant predictor factors for pathologic partial response. Using the receiver operating characteristic curve analysis, the ratio of 2.5 MYC/CEP8 (sensitivity of 80% and specificity of 89.1%) or 7 MYC/nuclei copies (sensitivity of 80% and specificity of 73.9%) as the best cutoff in predicting a pathologic complete response was identified. Thus, MYC may have a role in chemosensitivity to AC and/or docetaxel drugs. Additionally, MYC amplification may be a predictor factor of pathologic response to the AC+T regimen in patients with breast cancer. Moreover, patients with an increased number of MYC copies showed pathologic complete response to this neoadjuvant treatment more frequently. Conclusion: The analysis of MYC amplification may help in the identification of patients that may have a better response to AC+T treatment. (C) 2016 Elsevier Inc. All rights reserved.
ISSN: 1526-8209
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