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dc.contributor.authorGuzzoni, Vinicius
dc.contributor.authorCunha, Tatiana Sousa [UNIFESP]
dc.contributor.authordas Neves, Vander Jose
dc.contributor.authorBriet, Larissa
dc.contributor.authorCosta, Rafaela
dc.contributor.authorCosta Sampaio Moura, Maria Jose
dc.contributor.authorOliveira, Vanessa [UNIFESP]
dc.contributor.authorPinho Franco, Maria do Carmo [UNIFESP]
dc.contributor.authorNovaes, Pedro Duarte
dc.contributor.authorMarcondes, Fernanda Klein
dc.identifier.citationSteroids. New York, v. 131, p. 41456, 2018.-
dc.description.abstractAnabolic Androgenic Steroids (AASs) misuse has increased among adolescents and recreational athletes due to their potential effects on muscle hypertrophy. On the other hand, AAS might induce alterations on cardiovascular system, although some controversies regarding AAS on vascular properties remain unknown. To address this question, we aimed to investigate the effects of high doses of nandrolone combined with strenuous resistance training (RT) on function and structure of thoracic aorta. Rats were randomized into four groups: non-trained vehicle (NTV), trained vehicle (TV), non-trained nandrolone (NTN), and trained nandrolone (TN), and submitted to 6 weeks of treatment with nandrolone (5 mg/kg, twice a week) and/or resistance training. In vitro response of thoracic aorta to acetylcholine (ACh) was analyzed. Vascular nitric oxide (NO) and reactive oxygen species (ROS) synthesis were evaluated using 4,5-diaminofluorescein diacetate (DAF-2) and hydroethidine fluorescent techniques, respectively. Thoracic aorta was processed for microscopy analyses and tunica media thickness was measured. ACh-mediated relaxation response was impaired in endothelium intact aortic rings isolated from trained rats (TV and TN) as compared with their matched non-trained groups. TN rats showed reduced ACh-mediated vasodilatation than NTN rats. NO production and bioavailability decreased in thoracic aorta of nandrolone-treated rats in relation to their matched non-trained group (NTN vs. NWen
dc.description.abstractTN vs. TV). ROS production and tunica media thickness were increased in TN rats when compared with TV rats. These findings indicate that high doses of nandrolone combined with strenuous RT affect NO bioavailability and might induce endothelial dysfunction and arterial morphological alterations.en
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.publisherElsevier Science Inc
dc.rightsAcesso restrito
dc.subjectResistance trainingen
dc.subjectNitric oxideen
dc.subjectReactive oxygen speciesen
dc.titleNandrolone combined with strenuous resistance training reduces vascular nitric oxide bioavailability and impairs endothelium-dependent vasodilationen
dc.description.affiliationUniv Campinas FOP UNICAMP, Piracicaba Dent Sch, Dept Oral Physiol, Piracicaba, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sci & Technol Inst, Sao Jose Dos Campos, Brazil
dc.description.affiliationPontifical Catholic Univ Campinas PUC, Fac Med Sci, Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sch Med, Nephrol Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sci & Technol Inst, Sao Jose Dos Campos, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med, Nephrol Div, Sao Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 07/57380-9
dc.description.sourceWeb of Science
dc.coverageNew York
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