Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/5366
Title: Cystatin C and renal function in pediatric kidney transplant recipients
Authors: Franco, Maria do Carmo Pinho [UNIFESP]
Nagasako, Samantha Santiago [UNIFESP]
Machado, Paula Goulart Pinheiro [UNIFESP]
Nogueira, Paulo Cesar Koch [UNIFESP]
Pestana, Jose Osmar Medina [UNIFESP]
Sesso, Ricardo de Castro Cintra [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Children
Kidney transplant
Cystatin C
Creatinine
Glomerular filtration rate
Issue Date: 1-Dec-2009
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 12, p. 1225-1229, 2009.
Abstract: In clinical practice, the glomerular filtration rate (GFR) is often determined with serum creatinine. However, studies have shown cystatin C to be a better parameter for the diagnosis of impaired renal function. We compared GFR estimated by plasma cystatin C with GFR estimated by serum creatinine in a sample of 50 pediatric renal transplant recipients and 24 healthy children. The correlation between GFR estimated by serum creatinine and by cystatin C was significant (r = 0.75; P < 0.001, Person’s correlation); however, in pediatric kidney transplant recipients, the GFR was 6.7 mL/min lower when determined using cystatin C rather than serum creatinine. Moreover, using GFR estimated by cystatin C we found that 42% of the pediatric kidney transplant recipients had an estimated GFR <60 mL·min-1·1.73 (m²)-1, whereas when GFR was estimated by the serum creatinine formula only 16% of the children had values below this cutoff point indicative of chronic kidney disease (P < 0.001). We conclude that, in pediatric kidney transplant recipients, estimation of GFR yields lower values when cystatin C is used rather than serum creatinine.
URI: http://repositorio.unifesp.br/handle/11600/5366
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/S0100-879X2009007500003
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Artigo

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