Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/532
Title: Pulmonary emphysema induced by passive smoking: an experimental study in rats
Authors: Cendon Filha, Sônia Perez [UNIFESP]
Battlehner, Claudia
Lorenzi-Filho, Geraldo
Dohlnikoff, Marisa
Pereira, Patricia M [UNIFESP]
Conceição, Gleice M S [UNIFESP]
Beppu, Osvaldo Shigueomi [UNIFESP]
Saldiva, Paulo Hilário Nascimento
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: passive smoking
emphysema
rats
pulmonary function
morphological analysis
quantification
Issue Date: 1-Oct-1997
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 30, n. 10, p. 1241-1247, 1997.
Abstract: We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45 = 6.33; s-90 = 6.46; controls = 3.78; P<0.05). When the two groups of smoking rats were pooled together and compared to controls, they showed decreased lung elastance (1.6 vs 2.19; P = 0.046) and increased mean linear intercept (Lm) (85.14 vs 66.44; P = 0.025). The s-90 animals presented higher inflammation and muscular hypertrophy at the level of the axial bronchus than the controls (P<0.05). When smoking groups were pooled and compared to controls, they presented significantly higher inflammation at the lateral level (P = 0.028), as well as airway secretory hyperplasia (P = 0.024) and smooth muscle hypertrophy (P = 0.005) at the axial level. Due to its simplicity, low cost and short duration, this technique may be a useful model to obtain new information about airspace remodeling due to chronic tobacco consumption
URI: http://repositorio.unifesp.br/handle/11600/532
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/S0100-879X1997001000017
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