Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/51506
Title: Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway
Authors: Kanchanatawan, Buranee
Sirivichayakul, Sunee
Thika, Supaksorn
Ruxrungtham, Kiat
Carvalho, Andre F.
Geffard, Michel
Anderson, George
Noto, Cristiano [UNIFESP]
Ivanova, Rada
Maes, Michael
Keywords: Schizophrenia
Depression
Chronic fatigue
Neurocognitive impairments
immune
Cytokines
Leaky gut
Inflammation
Issue Date: 2017
Publisher: Springer/Plenum Publishers
Citation: Metabolic Brain Disease. New York, v. 32, n. 4, p. 1003-1016, 2017.
Abstract: To investigate the frequency of physio-somatic symptoms (PS) symptoms in schizophrenia and their relation to positive, negative and affective symptoms
neurocognitive deficits and impairments in the tryptophan catabolite (TRYCAT) pathway. Eighty four patients with schizophrenia and 40 healthy controls were assessed using the 12 item Fibromyalgia and Chronic Fatigue Syndrome Rating scale (FF) and scales for negative and positive symptoms, depression and anxiety. Cognitive functioning was tested using the Cambridge Neuropsychological Test Automated Battery (CANTAB). Other assessments included: immunoglobulin (Ig)A and IgM responses to tryptophan catabolites (TRYCATs), namely quinolinic (QA), 3-OH-kynurenine (3HK), picolinic (PA), xanthurenic (XA) and kynurenic acid (KA) and anthranilic acid (AA). More than 50% of the patients studied had elevated levels of physio-somatic (PS) symptoms, significantly co-occurring with depression and anxiety, but not with negative or positive symptoms. PS symptoms were significantly associated with IgA/IgM responses to TRYCATs, including increased IgA responses to 3 HK, PA and XA, and lowered IgA to QA and AA. Fatigue, muscle pain and tension, autonomic and cognitive symptoms and a flu-like malaise were strongly associated with cognitive impairments in spatial planning and working memory, paired associative learning, visual sustained attention and attention set shifting. PS symptoms in schizophrenia aggregate with depression and anxiety symptoms and may be driven by TRYCAT patterning of IgA/IgM-responses, with IgA indicating mucosal-mediated changes and IgM indicating regulatory functions. As such, the patterning of IgA/IgM responses to TRYCATs may indicate differential TRYCATs regulation of neuronal and glia activity that act to regulate PS signalling in schizophrenia.
URI: http://repositorio.unifesp.br/handle/11600/51506
ISSN: 0885-7490
Other Identifiers: http://dx.doi.org/10.1007/s11011-017-9982-7
Appears in Collections:Artigo

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.