Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/51487
Title: NO control of mitochondrial function in normal and transformed cells
Authors: Tengan, Celia H. [UNIFESP]
Moraes, Carlos T.
Keywords: Nitric oxide
Nitric oxide synthase
Mitochondria
Cancer
Respiratory chain
Issue Date: 2017
Publisher: Elsevier Science Bv
Citation: Biochimica Et Biophysica Acta-Bioenergetics. Amsterdam, v. 1858, n. 8, p. 573-581, 2017.
Abstract: Nitric oxide (NO) is a signaling molecule with multiple facets and involved in numerous pathological process, including cancer. Among the different pathways where NO has a functionally relevant participation, is the control of mitochondrial respiration and biogenesis. NO is able to inhibit the electron transport chain, mainly at Complex IV, regulating oxygen consumption and ATP generation, but at the same time, can also induce increase in reactive oxygen and nitrogen species. The presence of reactive species can induce oxidative damage or participate in redox signaling. In this review, we discuss how NO affects mitochondrial respiration and mitochondrial biogenesis, and how it influences the development of mitochondrial deficiency and cancer. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. (C) 2017 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/51487
ISSN: 0005-2728
Other Identifiers: http://dx.doi.org/10.1016/j.bbabio.2017.02.009
Appears in Collections:Artigo

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