Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/51479
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dc.contributor.authorde Oliveira Dias, Joao Rafael [UNIFESP]
dc.contributor.authorde Andrade, Gabriel Costa [UNIFESP]
dc.contributor.authorKniggendorf, Vinicius Ferreira [UNIFESP]
dc.contributor.authorNovais, Eduardo Amorim [UNIFESP]
dc.contributor.authorMaia, Andre [UNIFESP]
dc.contributor.authorMeyer, Carsten [UNIFESP]
dc.contributor.authorWatanabe, Sung Eun Song [UNIFESP]
dc.contributor.authorFarah, Michel Eid [UNIFESP]
dc.contributor.authorRodrigues, Eduardo Buschele [UNIFESP]
dc.date.accessioned2019-08-19T11:50:07Z-
dc.date.available2019-08-19T11:50:07Z-
dc.date.issued2017
dc.identifierhttp://dx.doi.org/10.1097/IAE.0000000000001385
dc.identifier.citationRetina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 37, n. 8, p. 1499-1507, 2017.
dc.identifier.issn0275-004X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51479-
dc.description.abstractPurpose: To evaluate the 6-month safety and efficacy of ziv-aflibercept intravitreal injections for treating exudative age-related macular degeneration. Methods: Fifteen patients with unilateral exudative age-related macular degeneration were enrolled. The best-corrected visual acuity was measured and spectral domain optical coherence tomography was performed at baseline and monthly. Full-field electroretinography and multifocal electroretinography were obtained at baseline and 4, 13, and 26 weeks after the first injection. All patients received three monthly intravitreal injections of ziv-aflibercept (1.25 mg) followed by as-needed treatment. Results: Between baseline and 26 weeks, the mean logMAR best-corrected visual acuity improved (P = 0.00408) from 0.93 +/- 0.4 (20/200) to 0.82 +/- 0.5 (20/160) logarithm of the minimum angle of resolution, respectivelyen
dc.description.abstractthe central retinal thickness decreased significantly (P = 0.0007) from 490.3 +/- 155.1 microns to 327.9 +/- 101.5 micronsen
dc.description.abstractthe mean total macular volume decreased significantly (P < 0.0001) from 9.51 +/- 1.36 mm(3) to 8.08 +/- 1.34 mm(3), and the a-wave implicit time increased, with no differences in the other full-field electroretinography parameters. The average multifocal electroretinography macular responses within the first central 15 degrees showed significantly (P < 0.05) increased P-1 amplitudes at 26 weeks. No systemic or ocular complications developed. Conclusion: Intravitreal ziv-aflibercept significantly improved the best-corrected visual acuity, multifocal electroretinography amplitudes, central retinal thickness, and total macular volume from baseline to 26 weeks. No retinal toxicity on full-field electroretinography or adverse events occurred during the follow-up period.en
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de São Paulo (São Paulo, Brazil)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (Brasilia, Brazil)
dc.description.sponsorshipPan-American Association of Ophthalmology/Pan-American Ophthalmological Foundation, Paul Kayser Global Award, Arlington, TX
dc.format.extent1499-1507
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.rightsAcesso aberto
dc.subjectziv-aflibercepten
dc.subjectage-related macular degenerationen
dc.subjectfull-field electroretinographyen
dc.subjectmultifocal electroretinographyen
dc.titleCLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION AFTER INTRAVITREAL ZIV-AFLIBERCEPT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATIONen
dc.typeArtigo
dc.description.affiliationUniv Fed São Paulo, Paulista Med Sch, Dept Ophthalmol, Rua Botucatu 821,1st Floor, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, Paulista Med Sch, Dept Ophthalmol, Rua Botucatu 821,1st Floor, BR-04023062 São Paulo, Brazil
dc.identifier.fileWOS000406108700010.pdf
dc.identifier.doi10.1097/IAE.0000000000001385
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000406108700010
Appears in Collections:Artigo

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