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Title: Genetic variants in gastric cancer: Risks and clinical implications
Authors: Gigek, Carolina Oliveira [UNIFESP]
Calcagno, Danielle Queiroz
Rasmussen, Lucas Trevizani
Santos, Leonardo Caires [UNIFESP]
Leal, Mariana Ferreira [UNIFESP]
Wisnieski, Fernanda [UNIFESP]
Burbano, Rommel Rodriguez
Lourenco, Laercio Gomes [UNIFESP]
Lopes-Filho, Gaspar Jesus [UNIFESP]
Cardoso Smith, Marilia Arruda [UNIFESP]
Keywords: Gastric cancer
mRNA expression
Issue Date: 2017
Publisher: Academic Press Inc Elsevier Science
Citation: Experimental And Molecular Pathology. San Diego, v. 103, n. 1, p. 101-111, 2017.
Abstract: Cancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies. The challenge is to better understand the mechanisms and different pathways that lead to the development and progression of GC.
ISSN: 0014-4800
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Appears in Collections:Artigo

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