Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/51340
Title: Improved cardiovascular autonomic modulation in transgenic rats expressing an Ang-(1-7)-producing fusion protein
Authors: Dartora, Daniela Ravizzoni
Irigoyen, Maria-Claudia
Casali, Karina Rabello [UNIFESP]
Moraes-Silva, Ivana C.
Bertagnolli, Mariane
Bader, Michael
Santos, Robson A. S.
Keywords: renin-angiotensin system
angiotensin-(1-7)
A-779
blood pressure
autonomic nervous system
heart rate variability
spectral analysis
Issue Date: 2017
Publisher: Canadian Science Publishing, Nrc Research Press
Citation: Canadian Journal Of Physiology And Pharmacology. Ottawa, v. 95, n. 9, p. 993-998, 2017.
Abstract: Angiotensin-(1-7) counterbalances angiotensin II cardiovascular effects. However, it has yet to be determined how cardiovascular autonomic modulation may be affected by chronic and acute elevation of Ang-(1-7). Hemodynamics and cardiovascular autonomic profile were evaluated in male Sprague-Dawley (SD) rats and transgenic rats (TGR) overexpressing Ang-(1-7) [TGR(A1-7) 3292]. Blood pressure (BP) was directly measured while cardiovascular autonomic modulation was evaluated by spectral analysis. TGR received A-779 or vehicle and SD rats received Ang-(1-7) or vehicle and were monitored for 5 h after i.v. administration. In another set of experiments with TGR, A-779 was infused for 7 days using osmotic mini pumps. Although at baseline no differences were observed, acute administration of A-779 in TGR produced a marked long-lasting increase in BP accompanied by increased BP variability (BPV) and sympathetic modulation to the vessels. Likewise, chronic administration of A-779 with osmotic mini pumps in TGR increased heart rate, sympathovagal balance, BPV, and sympathetic modulation to the vessels. Administration of Ang-(1-7) to SD rats increased heart rate variability values in 88% accompanied by 8% of vagal modulation increase and 18% of mean BP reduction. These results show that both acute and chronic alteration in the Ang-(1-7)-Mas receptor axis may lead to important changes in the autonomic control of circulation, impacting either sympathetic and (or) parasympathetic systems.
URI: http://repositorio.unifesp.br/handle/11600/51340
ISSN: 0008-4212
Other Identifiers: http://dx.doi.org/10.1139/cjpp-2016-0557
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