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dc.contributor.authorSiqueira, Camila Monteiro
dc.contributor.authorMotta, Priscila Dias
dc.contributor.authorCardoso, Thayna Neves
dc.contributor.authorCoelho, Cideli de Paula
dc.contributor.authorPopi, Ana Flavia [UNIFESP]
dc.contributor.authorCouceiro, Jose Nelson
dc.contributor.authorBonamin, Leoni Villano
dc.contributor.authorHolandino, Carla
dc.identifier.citationHomeopathy. Oxford, v. 105, n. 3, p. 257-264, 2016.
dc.description.abstractBackground: Influenza affects thousands of people worldwide every year, motivating the development of new therapies. In this work, the effects of two homeopathic preparations (influenza biotherapies and thymulin) were chosen following two different rationales: isotherapy and endo-isotherapy models. The homeopathic effects were evaluated individually considering the inflammatory and behavioral responses against influenza virus antigen were studied in BALB/c mice. Methods: Male adult mice were treated orally and blindly for 21 days with highly diluted influenza virus or with thymulin, and were divided in two sets of experiments. The first series of experiments aimed to describe their behavior, using an open field (OF) device. In the second series, mice were challenged subcutaneously with influenza hemagglutinin antigen (7 mu g/200 mu l) at day 21. At day 42, behavior and inflammation response were evaluated. Results: No behavioral changes were seen in OF tests at any time point after treatments. Flow cytometry and morphometry revealed significant changes in T and B cell balance after influenza antigen challenge, varying according to treatment. Conclusion: The results show that both homeopathic treatments induced subtle changes in acquired immune anti-viral response regulation. A deeper understanding of the mechanism could elucidate their possible use in influenza epidemiological situations.en
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.publisherElsevier Sci Ltd
dc.rightsAcesso restrito
dc.subjectInfluenza virusen
dc.subjectInfluenza hemagglutinin antigenen
dc.titleHomeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c miceen
dc.description.affiliationUniv Fed Rio de Janeiro, Rio De Janeiro, Brazil
dc.description.affiliationFed Inst Rio de Janeiro, Rio De Janeiro, Brazil
dc.description.affiliationUniv Paulista, Sao Paulo, Brazil
dc.description.affiliationUniv Santo Amaro, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
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