Please use this identifier to cite or link to this item:
|Title:||Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance|
|Authors:||Molin Netto, Barbara Dal [UNIFESP]|
Earthman, Carrie P.
Bettini, Solange Cravo
Grotti Clemente, Ana Paula [UNIFESP]
Landi Masquio, Deborah Cristina [UNIFESP]
da Silva, Larissa Gabrielle
von der Heyde, Maria Emilia
Damaso, Ana Raimunda [UNIFESP]
|Publisher:||Lippincott Williams & Wilkins|
|Citation:||European Journal Of Gastroenterology & Hepatology. Philadelphia, v. 28, n. 9, p. 1050-1055, 2016.|
|Abstract:||Introduction Body weight varies depending on the prevailing direction of environmental pressures|
however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results The BMI decreased from 44.3 +/- 6.4 to 31.7 +/- 5.7 kg/m(2) (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2 +/- 25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator alpha-melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion In the present investigation, it was found that there is a relationship between a-melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
|Appears in Collections:||Artigo|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.