Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/49708
Title: Impact of neonatal anoxia on adult rat hippocampal volume, neurogenesis and behavior
Authors: Takada, Silvia Honda
Motta-Teixeira, Livia Clemente
Machado-Nils, Aline Vilar
Lee, Vitor Yonamine
Sampaio, Carlos Alberto
Polli, Roberson Saraiva [UNIFESP]
Malheiros, Jackeline Moraes [UNIFESP]
Takase, Luiz Fernando
Kihara, Alexandre Hiroaki
Covolan, Luciene [UNIFESP]
Xavier, Gilberto Fernando
Nogueira, Maria Ines
Keywords: Neonatal anoxia
MRI
Hippocampal neurogenesis
Working memory
AnxietyHypoxic-Ischemic Encephalopathy
Preterm Fetal Sheep
Brain-Injury
Perinatal Asphyxia
Transient Hypoxia
Cerebral-Palsy
Spatial Memory
Model
Cells
Proliferation
Issue Date: 2016
Publisher: Elsevier Science Bv
Citation: Behavioural Brain Research. Amsterdam, v. 296, p. 331-338, 2016.
Abstract: Neonates that suffer oxygen deprivation during birth can have long lasting cognitive deficits, such as memory and learning impairments. Hippocampus, one of the main structures that participate in memory and learning processes, is a plastic and dynamic structure that conserves during life span the property of generating new cells which can become neurons, the so-called neurogenesis. The present study investigated whether a model of rat neonatal anoxia, that causes only respiratory distress, is able to alter the hippocampal volume, the neurogenesis rate and has functional implications in adult life. MRI analysis revealed significant hippocampal volume decrease in adult rats who had experienced neonatal anoxia compared to control animals for rostra!, caudal and total hippocampus. In addition, these animals also had 55.7% decrease of double-labelled cells to BrdU and NeuN, reflecting a decrease in neurogenesis rate. Finally, behavioral analysis indicated that neonatal anoxia resulted in disruption of spatial working memory, similar to human condition, accompanied by an anxiogenic effect. The observed behavioral alterations caused by oxygen deprivation at birth might represent an outcome of the decreased hippocampal neurogenesis and volume, evidenced by immunohistochemistry and MRI analysis. Therefore, based on current findings we propose this model as suitable to explore new therapeutic approaches. (C) 2015 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/49708
ISSN: 0166-4328
Other Identifiers: http://dx.doi.org/10.1016/j.bbr.2015.08.039
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