Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/49577
Title: Thyroid-specific genes expression uncovered age-related differences in pediatric thyroid carcinomas
Authors: Cordioli, Maria Isabel Cunha Vieira [UNIFESP]
Moraes, Lais [UNIFESP]
Alves, Maria Teresa de Seixas [UNIFESP]
Delcelo, Rosana [UNIFESP]
Monte, Osmar
Longui, Carlos Alberto
Cury, Adriano Namo
Cerutti, Janete Maria [UNIFESP]
Keywords: Sodium-Iodide Symporter
Young-Adults
Cancer
Children
Adolescents
Childhood
Radioiodine
Metabolism
Recurrence
Experience
Issue Date: 2016
Publisher: Hindawi publishing corp
Citation: International Journal Of Endocrinology. New York, 2016.
Abstract: Despite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pediatric patients might be associated with an increased expression of NIS. However, a marked heterogeneity within the pediatric group has been recognized. Children (<10 years old) usually present a more aggressive disease than adolescents (>= 10-18 years old). By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (P < 0.05). A linear regression confirmed the association between NIS expression and age. Most significantly, NIS was expressed at similar levels in DTC from children and adults, whereas PDS and TSHR expression was even lower in DTC from children, compared to adolescents and adults. Our data suggest that biological behaviors of DTC in adolescents might differ from those in children and adults. Therefore, the premise that the expression of thyroid-specific genes is higher in tumors from pediatric patients than in adults is not entirely true and might be too oversimplified.
URI: http://repositorio.unifesp.br/handle/11600/49577
ISSN: 1687-8337
Other Identifiers: http://dx.doi.org/10.1155/2016/1956740
Appears in Collections:Artigo
Artigo

Files in This Item:
File SizeFormat 
WOS000372238800001.pdf1.43 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.