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Title: Serum cytokine responses over the entire clinical-immunological spectrum of human leishmania (l.) infantum chagasi infection
Authors: Ramos, Patricia Karla
Carvalho, Karina Inacio
Rosa, Daniela Santoro [UNIFESP]
Rodrigues, Ana Paula
Lima, Luciana Vieira
Campos, Marliane Batista
Gomes, Claudia Maria C.
Laurenti, Marcia Dalastra
Corbett, Carlos Eduardo
Silveira, Fernando Tobias
Keywords: Human Visceral Leishmaniasis
Issue Date: 2016
Publisher: Hindawi ltd
Citation: Biomed Research International. London, 2016.
Abstract: The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi infection in Amazonian Brazil was recently reviewed based on clinical, DTH, and IFAT (IgG) evaluations that identified five profiles: three asymptomatic (asymptomatic infection, AI
subclinical resistant infection, SRI
and indeterminate initial infection, III) and two symptomatic (symptomatic infection, SI
American visceral leishmaniasis, AVL
and subclinical oligosymptomatic infection, SOI). TNF-alpha, IL-4, IL-6, and IL-10 serum cytokines were analyzed using multiplexed Cytometric Bead Array in 161 samples from endemic areas in the Brazilian Amazon: SI [AVL] (21 cases), III (49), SRI (19), SOI (12), AI (36), and a control group [CG] (24). The highest IL-6 serumlevels were observed in the SI profile (AVL)
higher IL-10 serum levels were observed in SI than in SOI or CG and in AI and III than in SOI
higher TNF-alpha serum levels were seen in SI than in CG. Positive correlations were found between IL-6 and IL-10 serum levels in the SI and III profiles and between IL-6 and TNF-alpha and between IL-4 and TNF-alpha in the III profile. These results provide strong evidence for associating IL-6 and IL-10 with the immunopathogenesis of AVL and help clarify the role of these cytokines in the infection spectrum.
ISSN: 2314-6133
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