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Title: The emerging role of mirnas and their clinical implication in biliary tract cancer
Authors: Ferreira Martins, Nina Nayara
da Silva Oliveira, Kelly Cristina
Bona, Amanda Braga
Cardoso Smith, Marilia de Arruda [UNIFESP]
Ishak, Geraldo
Assumpcao, Paulo Pimentel
Burbano, Rommel Rodriguez
Calcagno, Danielle Queiroz
Keywords: Intrahepatic Cholangiocarcinoma Cells
North Indian Population
Gallbladder Cancer
Mesenchymal Transition
Epigenetic Regulation
Issue Date: 2016
Publisher: Editora Unilasalle
Citation: Gastroenterology Research And Practice. New york, 2016.
Abstract: Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra-and extrahepatic ducts and have a poor prognosis. Surgical resection remains themain curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several singlenucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.
ISSN: 1687-6121
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Appears in Collections:Artigo

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