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Title: Comorbidity variation in patients with obsessive-compulsive disorder according to symptom dimensions: results from a large multicentre clinical sample
Authors: Torres, Albina Rodrigues
Fontenelle, Leonardo Franklin da Costa
Shavitt, Roseli Gedanke
Ferrão, Ygor Arzeno
Rosario, Maria Conceicao do [UNIFESP]
Storch, Eric A.
Miguel, Euripedes Constantino
Keywords: Obsessive-Compulsive Disorder
Symptom Dimensions
Comorbid DisordersOcd Collaborative Genetics
Temporal Stability
Hoarding Symptoms
Sexual Obsessions
Sibling Pairs
Issue Date: 2016
Publisher: Elsevier Science Bv
Citation: Journal Of Affective Disorders. Amsterdam, v. 190, p. 508-516, 2016.
Abstract: Background: Obsessive-compulsive disorder (OCD) has a heterogeneous and complex phenomenological picture, characterized by different symptom dimensions and comorbid psychiatric disorders, which frequently co-occur or are replaced by others over the illness course. To date, very few studies have investigated the associations between specific OCD symptom dimensions and comorbid disorders. Methods: Cross-sectional, multicenter clinical study with 1001 well-characterized OCD patients recruited within the Brazilian Research Consortium on Obsessive-Compulsive and Related Disorders. The primary instruments were the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS) and the Structured Clinical Interview for DSM-IV Axis I Disorders. Bivariate analyses between symptom dimensions and comorbidities were followed by logistic regression. Results: The most common comorbidities among participants (56.8% females) were major depression (56.4%), social phobia (34.6%), generalized anxiety disorder (34.3%), and specific phobia (31.4%). The aggressive dimension was independently associated with posttraumatic stress disorder (PTSD), separation anxiety disorder, any impulse-control disorder and skin picking
the sexual-religious dimension was associated with mood disorders, panic disorder/agoraphobia, social phobia, separation anxiety disorder, non-paraphilic sexual disorder, any somatoform disorder, body dysmorphic disorder and tic disorders
the contamination-cleaning dimension was related to hypochondriasis
and the hoarding dimension was associated with depressive disorders, specific phobia, PTSD, impulse control disorders (compulsive buying, skin picking, internet use), ADHD and tic disorders. The symmetry-ordering dimension was not independently associated with any comorbidity. Limitations: Cross-sectional design
participants from only tertiary mental health services
personality disorders not investigated. Conclusions: Different OCD dimensions presented some specific associations with comorbid disorders, which may influence treatment seeking behaviors and response, and be suggestive of different underlying pathogenic mechanisms. (C) 2015 Elsevier B.V. All rights reserved.
ISSN: 0165-0327
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