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dc.contributor.authorOliveira, Mayron Faria [UNIFESP]
dc.contributor.authorAlencar, Maria Clara [UNIFESP]
dc.contributor.authorArbex, Flavio [UNIFESP]
dc.contributor.authorSouza, Aline [UNIFESP]
dc.contributor.authorSperandio, Priscila [UNIFESP]
dc.contributor.authorMedina, Luiz [UNIFESP]
dc.contributor.authorMedeiros, Wladimir Musetti [UNIFESP]
dc.contributor.authorHirai, Daniel Müller [UNIFESP]
dc.contributor.authorO'Donnell, Denis E.
dc.contributor.authorNeder, Jose Alberto [UNIFESP]
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam, v. 221, p. 41-48, 2016.
dc.description.abstractCerebral blood flow (CBF) and oxygenation (COx) are generally well-preserved in COPD. It is unknown whether prevalent cardiovascular co-morbidities, such as heart failure, may impair CBF and COx responses to exertion. Eighteen males with moderate-to-severe COPD (8 with and 10 without overlapping heart failure) underwent a progressive exercise test with pre-frontal CBF and COx measurements (indocyanine green and near-infrared spectroscopy). Mean arterial pressure and cardiac output were lower from rest to exercise in overlap. Only COPD patients demonstrated an increase in arterialized PCO2 towards the end of progressive exercise. CBF index was consistently higher and increased further by similar to 40% during exercise in COPD whereas a similar to 10% reduction was observed in overlap. COx was lower in overlap despite preserved arterial oxygenation. In conclusion, heart failure introduces pronounced negative effects on CBF and COx in COPD which may be associated with clinically relevant outcomes, including dyspnea, exercise intolerance, cerebrovascular disease and cognitive impairment. (C) 2015 Elsevier B.V. All rights reserved.en
dc.publisherElsevier Science Bv
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.rightsAcesso aberto
dc.subjectCerebral Oxygenationen
dc.subjectChronic Obstructive Pulmonary Diseaseen
dc.subjectNear-Infrared SpectroscopyObstructive Pulmonary-Diseaseen
dc.subjectNear-Infrared Spectroscopyen
dc.subjectCerebrovascular Responsesen
dc.subjectNoninvasive Measurementen
dc.subjectEjection Fractionen
dc.subjectIndocyanine Greenen
dc.titleEffects of heart failure on cerebral blood flow in copd: rest and exerciseen
dc.description.affiliationPulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respirology, Federal University of Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationRespiratory Investigation Unit & Laboratory of Clinical Exercise Physiology, Queen’s University & Kingston General Hospital, Kingston, ON, Canada
dc.description.affiliationUnifespPulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respirology, Federal University of Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
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