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dc.contributor.authorCalcagno, Danielle Queiroz [UNIFESP]
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorSeabra, Aline Damaceno
dc.contributor.authorKhayat, Andre Salim
dc.contributor.authorChen, Elizabeth Suchi [UNIFESP]
dc.contributor.authorDemachki, Samia
dc.contributor.authorAssumpção, Paulo Pimentel [UNIFESP]
dc.contributor.authorGirao Faria, Mario Henrique
dc.contributor.authorRabenhorst, Silvia Helena Barem
dc.contributor.authorFerreira, Márcia Valéria Pitombeira
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez [UNIFESP]
dc.identifier.citationWorld Journal Of Gastroenterology. Beijing: W J G Press, v. 12, n. 38, p. 6207-6211, 2006.
dc.description.abstractAIM: To investigate chromosome 8 numerical aberrations, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histopathological characteristics of gastric tumors.METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immunostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed.RESULTS: All the cases showed chromosome 8 aneuploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level of chromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal-type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm.CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic pathways. (C) 2006 The WJG Press. All rights reserved.en
dc.publisherW J G Press
dc.relation.ispartofWorld Journal Of Gastroenterology
dc.rightsAcesso aberto
dc.subjectchromosome 8 aneuploidyen
dc.subjectC-MYC amplificationen
dc.subjectgastric adenocarcinomaen
dc.titleInterrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinomaen
dc.contributor.institutionFed Univ Para
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFed Univ Ceara
dc.description.affiliationFed Univ Para, Ctr Ciencias Biol, Dept Biol, Lab Citogenet Humana & Genet Toxicol, BR-66075900 Belem, Para, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Morphol, Div Genet, Sao Paulo, Brazil
dc.description.affiliationFed Univ Para, Dept Pathol, BR-66059 Belem, Para, Brazil
dc.description.affiliationFed Univ Para, Surg Serv, BR-66059 Belem, Para, Brazil
dc.description.affiliationFed Univ Para, Joao de Barros Barreto Univ Hosp, BR-66059 Belem, Para, Brazil
dc.description.affiliationFed Univ Ceara, Sch Med, Dept Pathol, Genet Mol Lab, Fortaleza, Ceara, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Morphol, Div Genet, Sao Paulo, Brazil
dc.description.sourceWeb of Science
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