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Title: Sleep Restriction during Pregnancy: Hypertension and Renal Abnormalities in Young Offspring Rats
Authors: Thomal, Janaina Thais [UNIFESP]
Palma, Beatriz Duarte [UNIFESP]
Ponzio, Beatriz Felice [UNIFESP]
Pinho Franco, Maria do Carmo [UNIFESP]
Zaladek-Gil, Frida [UNIFESP]
Fortes, Zuleica Bruno [UNIFESP]
Tufik, Sergio [UNIFESP]
Gomes, Guiomar Nascimento [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Sleep
renal function
glomerular hypertrophy
fetal programming
Issue Date: 1-Oct-2010
Publisher: Amer Acad Sleep Medicine
Citation: Sleep. Westchester: Amer Acad Sleep Medicine, v. 33, n. 10, p. 1357-1362, 2010.
Abstract: Study Objectives: Because the maternal environment can affect several physiological functions of the newborn, the aim of the present study was to examine the impact of sleep restriction during pregnancy on renal morphology and function in young offspring.Design: Female 3-month-old Wistar rats were divided in 2 experimental groups: C (control) and SR (sleep restriction between the 14th and 20th day of pregnancy). Pregnancy was confirmed by vaginal smear. SR females were subjected to sleep restriction by the multiple platform technique for 20 h daily. After birth, only male litters (6 for each mother) were selected and designated OC (offspring from C) and OSR (offspring from SR). At 2 months of age, blood pressure (BP) was measured by tail plethysmography; at 3 months the renal plasma flow (RPF), glomerular filtration rate (GFR), glomerular area, and number of glomeruli per mm(3) were evaluated.Measurements and Results: Offspring from SR had higher systolic blood pressure than OC. In this group (OSR), we also observed significant increase in RPF and GFR, enlarged glomeruli diameter, and reduced number of glomeruli per mm3 of renal tissue.Conclusions: Our data suggest that sleep restriction during pregnancy is able to modify renal development, resulting in morphologic and functional alterations in young offspring.
ISSN: 0161-8105
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