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Title: Canonical and noncanonical Wnt pathways: a comparison between endometrial cancer type I and atrophic endometrium in Brazil
Other Titles: Vias Wnt canônica e não canônica: uma comparação entre o câncer endometrial tipo I e endométrio atrófico no Brasil
Authors: Menezes, Marina de Pádua Nogueira [UNIFESP]
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Badiglian Filho, Levon [UNIFESP]
Gomes, Thiago Simao [UNIFESP]
Barrezueta, Luis Fernando Mesias [UNIFESP]
Stávale, João Norberto [UNIFESP]
Goncalves, Wagner Jose [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Wnt proteins
Endometrial neoplasms
Issue Date: 1-Jan-2011
Publisher: Associacao Paulista Medicina
Citation: Sao Paulo Medical Journal. Sao Paulo: Associacao Paulista Medicina, v. 129, n. 5, p. 320-324, 2011.
Abstract: CONTEXT AND OBJECTIVE: The Wnt pathway is involved in tumorigenesis of several tissues. For this reason, we proposed to evaluate Wnt gene expression in endometrial cancer type I.DESIGN AND SETTING: Cross-sectional study on materials gathered from the tissue bank of the Department of Pathology, Universidade Federal de Sao Paulo.METHODS: Endometrial specimens were obtained from surgeries performed between 1995 and 2005 at Sao Paulo Hospital, Universidade Federal de Sao Paulo. The material was divided into two groups according to tissue type: Group A, atrophic endometrium (n = 15); and Group B, endometrial adenocarcinoma (n = 45). We compared the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and beta-catenin between endometrial cancer type I and atrophic endometrium.RESULTS: Regarding Wnt1, FZD1 and Wnt5a expression, no significant association was observed between the groups. A significant association was observed between the groups in relation to FZD5 expression (P = 0.001). The proportion of FZD5-positive samples was significantly higher in group A (80.0%) than in group B (31.1%). Regarding the survival curve for FZD5 in group B, we did not find any significant association between atrophic endometrium and endometrial adenocarcinoma. We also did not find any significant association regarding beta-catenin expression (P = 1.000).CONCLUSION: FZD5 is downregulated in endometrial adenocarcinoma, in comparison with atrophic endometrium.
ISSN: 1516-3180
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