Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/45222
Title: Spectral-domain optical coherence tomography imaging of drusenoid pigment epithelial detachments
Authors: Garcia Filho, Carlos Alexandre de Amorim [UNIFESP]
Yehoshua, Zohar
Gregori, Giovanni
Farah, Michel Eid [UNIFESP]
Feuer, William
Rosenfeld, Philip J.
Univ Miami
Universidade Federal de São Paulo (UNIFESP)
Keywords: spectral-domain optical coherence tomography
SD-OCT
age-related macular degeneration
AMD
retinal pigmented epithelial detachment
PED
drusenoid PED
Issue Date: 1-Sep-2013
Publisher: Lippincott Williams & Wilkins
Citation: Retina-the Journal Of Retinal And Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 8, p. 1558-1566, 2013.
Abstract: Purpose: To evaluate drusenoid retinal pigment epithelial detachments (DPED) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography imaging.Methods: In this prospective natural history study, eyes from patients with the diagnosis of nonexudative AMD and DPEDs were followed for at least 6 months. Eyes were scanned using the Cirrus spectral-domain optical coherence tomography instrument and the 200 x 200 A-scan raster pattern. A custom software was used to quantify volumetric changes in DPEDs and to detect the evolution and formation of geographic atrophy and choroidal neovascularization. Changes in DPED area and volume and development of the advanced forms of AMD were the main outcome.Results: Of the 130 patients (186 eyes) with nonadvanced AMD, 11 patients (16 eyes) presented with DPEDs during the study. Mean follow-up was 18.5 months. Most DPEDs had an area exceeding 1 disk area (14 of 16 eyes) based on color fundus images with a mean area of 4.19 mm(2) (SD = 1.35) measured by spectral-domain optical coherence tomography. The mean volume at the time the DPED was diagnosed was 0.48 mm(3) (SD = 0.28). Four different patterns of progression were observed: DPEDs remained unchanged in 8 of 16 eyes (50%), DPEDs tended to increase in volume before progressing to geographic atrophy in 5 eyes (31.25%) and choroidal neovascularization in 2 eyes (12.5%), and a DPED decreased by more than 50% without progressing to geographic atrophy or choroidal neovascularization in 1 eye (6.25%).Conclusion: Spectral-domain optical coherence tomography imaging is able to detect subtle changes in the area and volume of DPEDs. Quantitative spectral-domain optical coherence tomography imaging of DPEDs is useful for identifying the natural history of disease progression and as a clinical tool for monitoring eyes with AMD in clinical trials.
URI: http://repositorio.unifesp.br/11600/45222
ISSN: 0275-004X
Other Identifiers: http://dx.doi.org/10.1097/IAE.0b013e318285cbd2
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