Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/45101
Title: Lipid metabolism of monosodium glutamate obese rats after partial removal of adipose tissue
Authors: Bueno, Allain Amador [UNIFESP] Amador [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Estadella, Debora [UNIFESP]
Habitante, Carlos Alexandre [UNIFESP]
Bernardes, Bruno Sérgio de Souza [UNIFESP]
Ribeiro, Eliane Beraldi [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: lipectomy
MSG rats
adipocyte area
lipogenesis rate
lipolysis rate
Issue Date: 1-Jan-2005
Publisher: Acad Sciences Czech Republic, Inst Physiology
Citation: Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 54, n. 1, p. 57-65, 2005.
Abstract: We analyzed the effects of partial fat pad removal on retroperitoneal and epididymal fat depots and carcass metabolism of control (C) and MSG-obese (M) rats. Three-month-old C and M male Wistar rats were submitted to either partial surgical excision of epididymal and retroperitoneal fat tissue (lipectomy, Q or sham surgery (S) and studied after 7 or 30 days. Retroperitoneal and epididymal tissue re-growth after lipectomy was not observed, as indicated by the low pads weight of the L groups. The lipolysis rate was stimulated in LC7 and LM7, probably due to surgical stress and low insulin levels. In LM7, but not in LC7, in vivo lipogenesis rate increased in retroperitoneal and epididymal fat tissue, as did the diet-derived lipid accumulation in epididymal fat tissue. Although these local increases were no longer present in LM30, this group showed a large increase in the percentage of small area adipocytes in both pads as well as increased carcass lipogenesis rate. The present data showed that the partial removal of fat depots affected the metabolism of control and MSG-obese rats differently. In the obese animals only, it stimulated both local and carcass lipogenesis rate as well as adipocyte differentiation, i.e. responses likely to favor excised tissue re-growth and/or compensatory growth of non-excised depots.
URI: http://repositorio.unifesp.br/11600/45101
ISSN: 0862-8408
Other Identifiers: http://www.biomed.cas.cz/physiolres/pdf/54/54_57.pdf
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