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dc.contributor.authorSchor, Ana Paula Torres
dc.contributor.authorCarvalho, Filomena Marino de [UNIFESP]
dc.contributor.authorKemp, Claudio [UNIFESP]
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.authorRusso, Jose
dc.identifier.citationOncology Reports. Athens: Professor D A Spandidos, v. 15, n. 1, p. 3-6, 2006.
dc.description.abstractBenign breast diseases represent the vast majority of diagnosis in breast pathology. However, the limited capability in identifying lesions at high risk of breast cancer evolution is an increasing problem in clinical practice. In the present study, we tested the hypothesis that the overexpression of S100P calcium-binding protein, previously identified in the very early stages of breast carcinogenesis, could be used as a marker to differentiate lesions at high risk of malignant evolution. In addition to S100P, the well-known proliferative marker, Ki-67, and estrogen receptor (ER) status were also assessed by immunohistochemistry in 155 samples from patients who submitted to stereotactic vacuum-assisted core biopsy due to breast microcalcifications. Results showed a positive association between ER and S100P overexpression, as well as a clear positive association between S100P overexpression and high-risk lesions. The strong association between S100P and ER expression highlights the hypothesis about the possible role played by S100P in the very early stages of breast carcinogenesis.en
dc.publisherProfessor D A Spandidos
dc.relation.ispartofOncology Reports
dc.rightsAcesso aberto
dc.subjectbreast proliferative lesionsen
dc.subjectcalcium-binding proteinen
dc.subjectestrogen receptoren
dc.titleS100P calcium-binding protein expression is associated with high-risk proliferative lesions of the breasten
dc.contributor.institutionFox Chase Canc Ctr
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionClin Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationFox Chase Canc Ctr, Breast Canc Res Lab, Philadelphia, PA 19111 USA
dc.description.affiliationUniv Sao Paulo, Dept Pathol, BR-05403000 Sao Paulo, Brazil
dc.description.affiliationClin Hosp, Div Pathol, BR-05403000 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Mol Gynecol Lab, BR-04039001 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Mol Gynecol Lab, BR-04039001 Sao Paulo, Brazil
dc.description.sourceWeb of Science
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